CD26 Antibody (5E8): sc-52642

CD26 Antibody (5E8) is a mouse monoclonal IgG1 kappa light chain antibody that detects CD26 protein of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-CD26 antibody (5E8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CD26, also known as dipeptidyl peptidase 4, adenosine deaminase complexing protein 2, and DPPIV, is a membrane glycoprotein and serine exopeptidase that plays a crucial role in immune regulation by cleaving X-proline dipeptides from the N-terminus of polypeptides. CD26 is primarily located on the surface of T cells, where CD26 functions as a co-stimulatory molecule that enhances T cell activation and regulates chemokine activity. This localization is vital for the immune response, as CD26 interacts with various proteins, including CXCR4 and gp120, which are implicated in the pathophysiology of HIV infection. CD26′s interaction with adenosine deaminase on dendritic cells facilitates a costimulatory signal in the immunological synapse, promoting the production of proinflammatory cytokines such as interferon-gamma, tumor necrosis factor-alpha, and interleukin-6. CD26 is involved in the pathogenesis of various human cancers, influencing the behavior of both solid tumors and hematological malignancies. The interaction between CD26 and caveolin-1 contributes to the up-regulation of CD86 on monocytes, which is essential for effective antigen-specific T cell activation.

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CD26 Antibody (5E8) References:

1. Regulation of CD26/DPPIV gene expression by interferons and retinoic acid in tumor B cells.  |  Bauvois, B., et al. 2000. Oncogene. 19: 265-72. PMID: 10645005
2. Internalization of CD26 by mannose 6-phosphate/insulin-like growth factor II receptor contributes to T cell activation.  |  Ikushima, H., et al. 2000. Proc Natl Acad Sci U S A. 97: 8439-44. PMID: 10900005
3. Comodulation of CXCR4 and CD26 in human lymphocytes.  |  Herrera, C., et al. 2001. J Biol Chem. 276: 19532-9. PMID: 11278278
4. Cloning and functional expression of the T cell activation antigen CD26.  |  Tanaka, T., et al. 1992. J Immunol. 149: 481-6. PMID: 1352530
5. T-cell activation via CD26 and caveolin-1 in rheumatoid synovium.  |  Ohnuma, K., et al. 2006. Mod Rheumatol. 16: 3-13. PMID: 16622717
6. 1F7 (CD26): a marker of thymic maturation involved in the differential regulation of the CD3 and CD2 pathways of human thymocyte activation.  |  Dang, NH., et al. 1991. J Immunol. 147: 2825-32. PMID: 1717577
7. Identification of Ia glycoproteins in rat thymus and purification from rat spleen.  |  McMaster, WR. and Williams, AF. 1979. Eur J Immunol. 9: 426-33. PMID: 315315
8. Association of Dipeptidylpeptidase 4 (CD26) With Chondrocyte Senescence and Radiographic Progression in Knee Osteoarthritis.  |  Chen, YH., et al. 2023. Arthritis Rheumatol. 75: 1120-1131. PMID: 36704903
9. CD26: a surface protease involved in T-cell activation.  |  Fleischer, B. 1994. Immunol Today. 15: 180-4. PMID: 7911022
10. Genomic organization, exact localization, and tissue expression of the human CD26 (dipeptidyl peptidase IV) gene.  |  Abbott, CA., et al. 1994. Immunogenetics. 40: 331-8. PMID: 7927537
11. Role of CD26 for CD4 memory T cell function and activation.  |  Dong, RP. and Morimoto, C. 1996. Hum Cell. 9: 153-62. PMID: 9183643
12. CD26/dipeptidyl peptidase IV in lymphocyte growth regulation.  |  Ansorge, S., et al. 1997. Adv Exp Med Biol. 421: 127-40. PMID: 9330689

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CD26 Antibody (5E8) has 18 citations in a variety of scientific publications.

Primary antibodies like Anti-CD26 Antibody (5E8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CD26 Antibody (5E8) Specifications

Alternate Product Name: DPP4

Product Clone Name: 5E8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: CD26

Epitope Species: rat

Product Reactivity/Detection: CD26

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 18 citations in various scientific publications

Available Conjugates/Forms for CD26 Antibody (5E8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin