PA Anticuerpo(BAP0102): sc-52124

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Bacillus anthracis, a Gram-positive bacterium, is capsulogenic and toxinogenic and is the causative agent of anthrax (1). Bacillus anthracis secretes two toxins, which are composed of three proteins: the protective antigen (PA), the lethal factor (LF) and the edema factor (EF) (1). PA and LF comprise a lethal toxin, which provokes a subite death in animals, whereas the edema toxin, comprised of PA and EF, induces edema (1). The edema and the lethal factors are internalized into the target cells via the protective antigen (1). PA is the target-cell binding protein and is common to the two effector molecules, LF and EF, which exert their toxic effects once they are translocated to the cytosol by PA (2). PA is the major component of vaccines against anthrax since it confers protective immunity (2). The large-scale production of recombinant protein-based anthrax vaccines requires overexpression of the PA protein (2). LF plays an important role in the pathogenesis of anthrax (3-5). In addition, EF and LF exert adenylate cyclase and metalloprotease activity, respectively (1).