SNX15 Anticuerpo(E-18): sc-49119

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Sorting nexin proteins (SNX) are members of a large family of hydrophilic proteins that interact with a variety of receptor types, contain a characteristic phox homology (PX) domain and are involved in intracellular trafficking. SNX15 encodes a deduced 342 amino acid protein, as well as a 256 amino acid splice variant known as SNX15A. Highest expression of SNX15 is observed in skeletal muscle, heart, brain, kidney, spleen, thymus and small intestine tissues. Endogenous and overexpressed SNX15 localize on membranes and in the cytosol. SNX15 associates with itself as well as with SNX1, SNX2, SNX4 and platelet-derived growth factor receptor (PDGFR). Overexpression of SNX15 leads to a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits, and also results in the mislocalization of Furin, the endoprotease accountable for cleavage of insulin and hepatocyte growth factor receptors.