α/β-SNAP Antibody (G-3): sc-48349
- α/β-SNAP Antibody (G-3) is a mouse monoclonal IgG1 κ α/β-SNAP antibody, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 1-295 representing full length α-SNAP of human origin
- alpha / beta-SNAP Antibody (G-3) is recommended for detection of α-SNAP and β-SNAP of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-alpha / beta-SNAP Antibody (G-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for α/β-SNAP Antibody (G-3) for WB and IHC(P) applications. These reagents are now offered in bundles with α/β-SNAP Antibody (G-3) (see ordering information below).
α/β-SNAP Antibody (G-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects α/β-SNAP of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). α/β-SNAP (G-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. α/β-SNAP plays a crucial role in exocytosis, which is essential for neurotransmitter release and other cellular secretion mechanisms. α/β-SNAP functions as a soluble NSF attachment protein that facilitates SNARE complex assembly, a critical component in vesicle fusion with target membranes. This process maintains proper synaptic transmission and cellular communication, making α/β-SNAP essential in both neuronal and non-neuronal cells. α/β-SNAP interaction with syntaxins and VAMPs underscores α/β-SNAP significance in regulating membrane fusion events. By providing a reliable tool for studying exocytosis dynamics, anti-α/β-SNAP antibody (G-3) is invaluable for researchers investigating synaptic function and related disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
α/β-SNAP Antibody (G-3) References:
- Expression of neuroendocrine markers: a signature of human undifferentiated carcinoma of the colon and rectum. | Grabowski, P., et al. 2002. Virchows Arch. 441: 256-63. PMID: 12242522
- Heterogeneous expression of neuroendocrine marker proteins in human undifferentiated carcinoma of the colon and rectum. | Grabowski, P., et al. 2004. Ann N Y Acad Sci. 1014: 270-4. PMID: 15153444
- A ubiquitous membrane fusion protein alpha SNAP: a potential therapeutic target for cancer, diabetes and neurological disorders? | Andreeva, AV., et al. 2006. Expert Opin Ther Targets. 10: 723-33. PMID: 16981829
- High affinity associations with α-SNAP enable calcium entry via Orai1 channels. | Ramanagoudr-Bhojappa, R., et al. 2021. PLoS One. 16: e0258670. PMID: 34653219
- The syntaxin family of vesicular transport receptors. | Bennett, MK., et al. 1993. Cell. 74: 863-73. PMID: 7690687
- Synaptobrevin binding to synaptophysin: a potential mechanism for controlling the exocytotic fusion machine. | Edelmann, L., et al. 1995. EMBO J. 14: 224-31. PMID: 7835333
- Synaptic core complex of synaptobrevin, syntaxin, and SNAP25 forms high affinity alpha-SNAP binding site. | McMahon, HT. and Südhof, TC. 1995. J Biol Chem. 270: 2213-7. PMID: 7836452
- Exocytosis relating proteins in the nervous system. | Yamaguchi, K. and Akagawa, K. 1994. Neurosci Res. 20: 289-92. PMID: 7870381
- Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly. | Hayashi, T., et al. 1994. EMBO J. 13: 5051-61. PMID: 7957071
- A role for synaptotagmin (p65) in regulated exocytosis. | Elferink, LA., et al. 1993. Cell. 72: 153-9. PMID: 8422678
- Stimulation of NSF ATPase activity by alpha-SNAP is required for SNARE complex disassembly and exocytosis. | Barnard, RJ., et al. 1997. J Cell Biol. 139: 875-83. PMID: 9362506
- Structural organization of the synaptic exocytosis core complex. | Lin, RC. and Scheller, RH. 1997. Neuron. 19: 1087-94. PMID: 9390521
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
α/β-SNAP Antibody (G-3) | sc-48349 | 200 µg/ml | $322.00 | |||
α/β-SNAP Antibody (G-3): m-IgG Fc BP-HRP Bundle | sc-528523 | 200 µg Ab; 10 µg BP | $361.00 | |||
α/β-SNAP Antibody (G-3): m-IgGκ BP-HRP Bundle | sc-520919 | 200 µg Ab, 40 µg BP | $361.00 | |||
α/β-SNAP Antibody (G-3): m-IgG1 BP-HRP Bundle | sc-542975 | 200 µg Ab; 20 µg BP | $361.00 | |||
α/β-SNAP Antibody (G-3) AC | sc-48349 AC | 500 µg/ml, 25% agarose | $424.00 | |||
α/β-SNAP Antibody (G-3) HRP | sc-48349 HRP | 200 µg/ml | $322.00 | |||
α/β-SNAP Antibody (G-3) FITC | sc-48349 FITC | 200 µg/ml | $336.00 | |||
α/β-SNAP Antibody (G-3) PE | sc-48349 PE | 200 µg/ml | $349.00 | |||
α/β-SNAP Antibody (G-3) Alexa Fluor® 488 | sc-48349 AF488 | 200 µg/ml | $364.00 | |||
α/β-SNAP Antibody (G-3) Alexa Fluor® 546 | sc-48349 AF546 | 200 µg/ml | $364.00 | |||
α/β-SNAP Antibody (G-3) Alexa Fluor® 594 | sc-48349 AF594 | 200 µg/ml | $364.00 | |||
α/β-SNAP Antibody (G-3) Alexa Fluor® 647 | sc-48349 AF647 | 200 µg/ml | $364.00 | |||
α/β-SNAP Antibody (G-3) Alexa Fluor® 680 | sc-48349 AF680 | 200 µg/ml | $364.00 | |||
α/β-SNAP Antibody (G-3) Alexa Fluor® 790 | sc-48349 AF790 | 200 µg/ml | $364.00 |