Nischarin Anticuerpo(C-16): sc-47236

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Integrins play important roles in key cellular functions, including cytoskeletal organization, growth, survival, motility and gene expression regulation. Nischarin is a novel intracellular protein, that binds to the cytoplasmic domain of integrin å5/∫1 and interacts with various members of the PAK family of kinases. Nischarin binding to PAK1 inhibits the ability of PAK1 to phosphorylate substrates. When bound, this complex localizes to membrane ruffles which are involved in cell motility. Nischarin also acts as an antagonist of Rac function on cell movement and alters actin filament organization. These functions give Nischarin a possible role in cell migration regulation. Nischarin is a primarily cytoplasmic protein primarily expressed in kidney and brain.