epitope mapping near the N-terminus of PCB of human origin
recommended for detection of PCB of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
PCB Background Information Pyruvate carboxylase (PCB) is a biotinylated mitchondrial enzyme that catalyzes the synthesis of oxaloacetate from pyruvate in a tissue specific manner. In addition to covalently binding the biotin cofactor, PCB contains consensus sequences for the attachment of ATP and the substrate pyruvate. The PCB gene is located on the long arm of chromosome 11. Mutations in PCB metabolism (pyruvate carboxylase deficiency) are known to cause lactic acidosis, hypoglycemia and mental retardation.
PCB (N-12)
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PCB (N-12): sc-46230. Western blot analysis of PCB expression in mouse liver (A) and rat kidney (B) tissue extracts.
PCB (N-12): sc-46230. Western blot analysis of PCB expression in non-transfected: sc-117752 (A) and mouse PCB transfected: sc-122419 (B) 293T whole cell lysates.
