CGNL1 Anticuerpo(E-6): sc-377525

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Diffusion of solutes is prevented across certain barriers by the formation of tight junction seals. Occludin and Cingulin interact with other proteins to direct the formation and regulation of tight junctions. Cingulin, a protein component of the submembrane plaque of tight junctions (TJ), contains globular and coiled-coil domains and interacts in vitro with several TJ and cytoskeletal proteins, including the PDZ protein ZO-1. CGNL1 (cingulin-like 1), also known as JACOP (junction-associated coiled-coil protein), is a 1.302 amino acid tight junction protein belonging to the Cingulin family. Expressed in smooth muscle, spleen, testis, fetal brain, amygdala, corpus callosum, cerebellum, thalamus and subthalamic nucleus of adult brain. CGNL1 exists as two alternatively spliced isoforms and is encoded by a gene located on human chromosome 15q21.3. CGNL1 may participate in anchoring the apical junctional complex, primarily tight junctions, to actin-based cytoskeletons. Mutations in the gene encoding CGNL1 are the cause of aromatase excess syndrome, which is characterized by an estrogen excess due to an increased aromatase activity.