FLAD1 Anticuerpo(G-4): sc-376819

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FLAD1 (FAD1 flavin adenine dinucleotide synthetase), also known as FAD1, FADS, PP591 or molybdenum cofactor biosynthesis protein-like, is a 587 amino acid protein where its N-terminus belongs to the moaB/mog family and its C-terminus belongs to the PAPS reductase family. Existing as five alternatively spliced isoforms, FLAD1 localizes to the cytoplasm and utilizes magnesium as a cofactor. FLAD1 is a key enzyme in the metabolic pathway that converts riboflavin into the redox cofactor flavin adenine dinucleotide (FAD). It is suggested that the molybdenum cofactor biosynthesis protein-like region of FLAD1 may not be functional. FLAD1 is encoded by a gene located on human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.