FGD3 Antibody (D-3): sc-376120
- FGD3 Antibody (D-3) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 1-75 mapping at the N-terminal of FGD3 of human origin
- recommended for detection of FGD3 of human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for FGD3 Antibody (D-3) for WB and IHC(P) applications. These reagents are now offered in bundles with FGD3 Antibody (D-3) (see ordering information below).
FGD3 Antibody (D-3) is a mouse monoclonal IgG1 antibody that detects FGD3 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). FGD3 plays a crucial role in cellular signaling as a guanine nucleotide exchange factor that specifically activates the Rho GTPase Cdc42, which is essential for the regulation of cytoskeletal dynamics and cell morphology. The activation of Cdc42 by FGD3 is particularly important during embryonic development, as FGD3 stimulates fibroblasts to form filopodia—actin-rich protrusions that facilitate cell movement and communication. This process is vital for proper tissue formation and organization, highlighting FGD3′s significance in developmental biology. Additionally, FGD3 shares a high degree of sequence identity with family members FGD1 and FGD2, which underscores the conserved nature of signaling mechanisms within the FGD family of Rho guanine nucleotide exchange factors. The presence of FGD proteins in various tissues during embryogenesis suggests their collective contribution to intricate signaling networks required for normal development and cellular function.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FGD3 Antibody (D-3) | sc-376120 | 200 µg/ml | $322.00 | |||
FGD3 Antibody (D-3): m-IgG Fc BP-HRP Bundle | sc-540516 | 200 µg Ab; 10 µg BP | $361.00 | |||
FGD3 Antibody (D-3): m-IgG1 BP-HRP Bundle | sc-542175 | 200 µg Ab; 20 µg BP | $361.00 |