SR-A Anticuerpo(E-10): sc-374130

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The macrophage class A scavenger receptor (SR-A) mediates the uptake of modified low density lipoprotein (LDL) (1). The gene encoding human SR-A maps to chromosome 8 and gives rise to two alternatively spliced isoforms, type I and II (SR-AI and SR-AII), which were originally cloned from the phorbol ester-treated human monocytic cell line THP-1 (2). Both isoforms contain six domains: cytoplasmic (I), membrane-spanning (II), spacer (III), alpha-helical coiled-coil (IV), collagen-like (V) and a type-specific C-terminal (VI) (2,3). Domain IV is essential for the trimerization of SR-A, whereas domain V is essential for the wide range of ligand recognition (3). SR-A is expressed in liver, placenta and brain (2). Both SR-AI and SR-AII mediate the uptake of LDLs in atherosclerotic lesions (2). A third isoform, SR-AIII, is unable to uptake LDLs and acts as a dominant negative isoform to possibly protect cells found in advanced atherosclerotic lesions (1,4). SR-A plays a role not only in many macrophage-associated pathological processes, including atherosclerosis and Alzheimer’s disease, but also in host defense and as an adhesion molecule (5,6).