CD6 Antibody (F-5): sc-373753

CD6 Antibody (F-5) is a mouse monoclonal IgG1 antibody that detects CD6 in human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). CD6 is a type I transmembrane glycoprotein predominantly expressed on mature thymocytes, peripheral T cells, and a subset of B cells, playing a crucial role in immune responses. CD6′s structure consists of a 24-amino acid signal sequence, three extracellular scavenger receptor cysteine-rich (SRCR) domains, a membrane-spanning domain, and a 44-amino acid cytoplasmic domain, which collectively facilitate function in T-cell activation and interaction with thymic epithelial cells. CD6 undergoes tyrosine phosphorylation during T-cell receptor-mediated activation, and variations in phosphorylation state contribute to size differences observed among CD6 forms. CD6 shares significant homology with CD5 and can physically associate with the TCR/CD3 complex, underscoring CD6′s importance in modulating T-cell responses and interactions within the immune system. Anti-CD6 antibody (F-5) serves as an essential tool for researchers studying T-cell biology and related immunological processes.

The preferred CD6 antibody is CD6 Antibody (SPV-L14): sc-7320.