ETFA Anticuerpo(H-8): sc-365982

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ETFA (electron-transfer-flavoprotein, alpha polypeptide), also known as EMA, GA2 or MADD, is a 333 amino acid protein that localizes to the mitochondrial matrix and belongs to the ETF alpha-subunit/fixB family. Existing as a heterodimer with ETFB, ETFA uses FAD as a cofactor and serves as a specific electron acceptor for several dehydrogenases, effectively transferring electrons to the mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase. Defects in the gene encoding ETFA are the cause of glutaric aciduria type IIA (GAIIA), a condition that is characterized by the excretion of lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, glutaric and isovaleric acids. The gene encoding ETFA maps to human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome.