WASP Antibody (F-8): sc-365859

WASP Antibody (F-8) is a mouse monoclonal IgG2a antibody that detects WASP in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). WASP, or Wiskott-Aldrich syndrome protein, plays a crucial role in the regulation of the actin cytoskeleton, which is essential for various cellular processes, including cell migration, shape, and division. WASP monoclonal antibody (F-8) is specific for an epitope mapping between amino acids 197-222 within an internal region of WASP of human origin. The proper functioning of WASP is particularly important in immune cells, where WASP facilitates the formation of actin-rich structures necessary for effective immune responses. Mutations in the WASP gene lead to the Wiskott-Aldrich syndrome, characterized by immunodeficiency and increased susceptibility to infections, highlighting WASP′s vital role in maintaining immune system integrity. WASP interacts with several key proteins, including Cdc42, a small GTPase that activates WASP, thereby linking extracellular signals to the cytoskeletal reorganization required for T cell activation and function. The ability of anti-WASP antibody (F-8) to modulate the actin cytoskeleton underscores WASP′s importance in both normal cellular physiology and the pathogenesis of immune disorders, making anti-WASP antibody (F-8) an invaluable tool for researchers studying these processes.

The preferred WASP antibody is WASP Antibody (B-9): sc-13139.