PLC δ1 Anticuerpo(A-4): sc-365812

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Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in the initiation of receptor-mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG) from phosphatidylinositol 4,5-bisphosphate. There are several mammalian PLC proteins, including PLC ∫1, PLC ∫2, PLC ∫3, PLC ∫4, PLC©1, PLC©2, PLC ∂1, PLC ∂3, PLC ∂4 and PLCe. PLC ∂1, a calcium signal amplifier, is activated by an atypical GTP-binding protein and functions as an effector for GTP-binding protein transglutaminase II-mediated oxytocin receptor and å1B-adrenoreceptor signaling. PLC ∂1 is highly expressed in brain, heart, lung and testis and is abnormally accumulated in autopsied brains with Alzheimer’s disease (AD), suggesting that it may play a role in the pathology of AD. Both PLC ∂3 and PLC ∂4 contain several functional domains through which they bind calcium as a cofactor and catalyze the creation of DAG and IP3, playing an essential role in signal transduction. PLC ∂4 is highly expressed in skeletal muscle and kidney tissue, as well as in corneal epithelial cells, suggesting a role in the regulation of kidney and ocular function.