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SAP 49 Anticuerpo(G-12): sc-365570

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(Basado en el análisis de datos)

  • SAP 49 Antibody (G-12) is a mouse monoclonal IgG1 provided at 200 µg/ml
  • specific for an epitope mapping between amino acids 192-213 within an internal region of SAP 49 of human origin
  • recommended for detection of SAP 49 of mouse and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
 

Ver tambiénSAP AntibodiesincluyebdoSAP, SAP 14, SAP 18, SAP 30, SAP 30BP, SAP 30L, SAP 49, SAP 61, SAP 62, SAP 114, SAP 130, SAP 145ySAP 155.

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 Información sobre pedidos
Nombre del productoNúmero de catálogoUnidadPrecioCantidadAñadir 
SAP 49 Antibody (G-12) sc-365570 200 µg/ml $279
 
Especies Nombre del Gen Gene ID Ubicación en el cromosoma Numero de Acceso de Isoforma (ARNm) Número de Acceso de la Proteína Número OMIM™:
Humano SF3B4 10262 1q21.2 NM_005850 Q15427
 605593
Ratón Sf3b4 107701 3 F2.1 NM_153053 Q8QZY9
 No Disponible
 

SF3b is a U2 snRNP-associated protein complex essential for spliceosome assembly. SF3b contains the spliceosomal proteins SAP 49, SAP 130, SAP 145, and SAP 155. SAP 130, SAP 145, and SAP 155 are present in a protein complex in HeLa nuclear extracts and associate with one another. While SAP 155 and SAP 130 interact with each other (directly or indirectly) within this complex, SAP 49 and SAP 145 are known to interact directly with each other. Unexpectedly, the SAP 49-SAP 145 protein-protein interaction requires the amino-terminus of SAP 49, which contains two RNA-recognition motifs. The observation that SAP 49 and SAP 145 interact directly with both U2 snRNP and the pre-mRNA suggests that this protein complex plays a role in tethering U2 snRNP to the branch site.
SAP 49 Antibody (G-12) Data
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sc-365570
SAP 49 (G-12): sc-365570. Western blot analysis of SAP 49 expression in non-transfected 293T: sc-117752 (A), mouse SAP 49 transfected 293T: sc-123349 (B) and MCF7 (C) whole cell lysates.
sc-365570
SAP 49 (G-12): sc-365570. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.
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