hnRNP L Antibody (4D11): sc-32317
- hnRNP L Antibody (4D11) is a mouse monoclonal IgG1 κ hnRNP L antibody, cited in 51 publications, provided at 200 µg/ml
- raised against human hnRNP proteins (from HeLa cells) purified by affinity chromatography on ssDNA agarose
- hnRNP L Antibody (4D11) is recommended for detection of hnRNP L of mouse, rat and human origin by WB, IP, IF and IHC(P)
- Anti-hnRNP L Antibody (4D11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for hnRNP L Antibody (4D11) for WB and IHC(P) applications. These reagents are now offered in bundles with hnRNP L Antibody (4D11) (see ordering information below).
hnRNP L Antibody (4D11) is a mouse monoclonal IgG1 kappa light chain antibody that detects hnRNP L protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. anti-hnRNP L antibody (4D11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The heterogeneous nuclear ribonucleoprotein L (hnRNP L) plays a crucial role in regulating gene expression, particularly in mRNA transcription, pre-mRNA processing, and mature mRNA transport to the cytoplasm for translation. hnRNP L is primarily localized in the nucleoplasm, where hnRNP L interacts with RNA and other proteins to influence alternative splicing mechanisms, which are vital for generating protein diversity and regulating cellular responses. hnRNP L, along with hnRNP I homolog, binds to the 3′ end of introns, thereby modulating splicing events that can affect the expression of various genes, including those involved in viral infections such as hepatitis C virus (HCV). hnRNP L′s ability to shuttle between the nucleus and cytoplasm further underscores hnRNP L′s importance in post-transcriptional regulation, making hnRNP L a significant target for studies related to gene expression and viral pathogenesis.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
hnRNP L Antibody (4D11) References:
- Nuclear pre-mRNA compartmentalization: trafficking of released transcripts to splicing factor reservoirs. | Melcák, I., et al. 2000. Mol Biol Cell. 11: 497-510. PMID: 10679009
- Protein-protein interaction among hnRNPs shuttling between nucleus and cytoplasm. | Kim, JH., et al. 2000. J Mol Biol. 298: 395-405. PMID: 10772858
- Organization of the human gene encoding heterogeneous nuclear ribonucleoprotein type I (hnRNP I) and characterization of hnRNP I related pseudogene. | Romanelli, MG., et al. 2000. Gene. 255: 267-72. PMID: 11024286
- A nuclear localization domain in the hnRNP A1 protein. | Siomi, H. and Dreyfuss, G. 1995. J Cell Biol. 129: 551-60. PMID: 7730395
- Identification and characterisation of a novel human RNA-binding protein. | Badolato, J., et al. 1995. Gene. 166: 323-7. PMID: 8543184
- Multiple RRMs contribute to RNA binding specificity and affinity for polypyrimidine tract binding protein. | Pérez, I., et al. 1997. Biochemistry. 36: 11881-90. PMID: 9305981
- Polypyrimidine tract-binding protein interacts with HnRNP L. | Hahm, B., et al. 1998. FEBS Lett. 425: 401-6. PMID: 9563502
- Heterogeneous nuclear ribonucleoprotein L interacts with the 3' border of the internal ribosomal entry site of hepatitis C virus. | Hahm, B., et al. 1998. J Virol. 72: 8782-8. PMID: 9765422
- Polypyrimidine tract-binding protein binds to the leader RNA of mouse hepatitis virus and serves as a regulator of viral transcription. | Li, HP., et al. 1999. J Virol. 73: 772-7. PMID: 9847386
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
hnRNP L Antibody (4D11) | sc-32317 | 200 µg/ml | $322.00 | |||
hnRNP L Antibody (4D11): m-IgG Fc BP-HRP Bundle | sc-528461 | 200 µg Ab; 10 µg BP | $361.00 | |||
hnRNP L Antibody (4D11): m-IgGκ BP-HRP Bundle | sc-520844 | 200 µg Ab, 40 µg BP | $361.00 | |||
hnRNP L Antibody (4D11): m-IgG1 BP-HRP Bundle | sc-542941 | 200 µg Ab; 20 µg BP | $361.00 | |||
hnRNP L Antibody (4D11) AC | sc-32317 AC | 500 µg/ml, 25% agarose | $424.00 | |||
hnRNP L Antibody (4D11) HRP | sc-32317 HRP | 200 µg/ml | $322.00 | |||
hnRNP L Antibody (4D11) FITC | sc-32317 FITC | 200 µg/ml | $336.00 | |||
hnRNP L Antibody (4D11) PE | sc-32317 PE | 200 µg/ml | $349.00 | |||
hnRNP L Antibody (4D11) Alexa Fluor® 488 | sc-32317 AF488 | 200 µg/ml | $364.00 | |||
hnRNP L Antibody (4D11) Alexa Fluor® 546 | sc-32317 AF546 | 200 µg/ml | $364.00 | |||
hnRNP L Antibody (4D11) Alexa Fluor® 594 | sc-32317 AF594 | 200 µg/ml | $364.00 | |||
hnRNP L Antibody (4D11) Alexa Fluor® 647 | sc-32317 AF647 | 200 µg/ml | $364.00 | |||
hnRNP L Antibody (4D11) Alexa Fluor® 680 | sc-32317 AF680 | 200 µg/ml | $364.00 | |||
hnRNP L Antibody (4D11) Alexa Fluor® 790 | sc-32317 AF790 | 200 µg/ml | $364.00 |