MPST Anticuerpo(H-49): sc-292174

---

MPST (mercaptopyruvate sulfurtransferase), also known as MST or TST2, is a 297 amino acid protein that localizes to the cytoplasm and contains two rhodanese domains. Existing as a monomer or as a dilsulfide-linked homodimer, MPST functions to catalyze the transfer of a sulfur ion to select thiol compounds, such as cyanide, and is thought to be involved in cyanide detoxification and cysteine degradation. MPST deficiency may be associated with the pathogenesis of the rare disorder mercaptolactate-cysteine disulfiduria (MCDU). The gene encoding MPST maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibromatosis type 2, autism and schizophrenia.