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p21 Anticuerpo(F-8): sc-271610

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  • p21 Antibody (F-8) is a mouse monoclonal IgG2a provided at 200 µg/ml
  • specific for an epitope mapping between amino acids 124-164 at the C-terminus of p21 of human origin
  • recommended for detection of p21 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine and porcine
  • See 1 citations for p21 Anticuerpo (F-8)
 

Ver tambiénp21 Antibodies.

También verp21 Activators for functional analysis of cellular responses to p21.


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 Información sobre pedidos
Nombre del productoNúmero de catálogoUnidadPrecioCantidadAñadir 
p21 Antibody (F-8) sc-271610 200 µg/ml $279
 
Especies Nombre del Gen Gene ID Ubicación en el cromosoma Numero de Acceso de Isoforma (ARNm) Número de Acceso de la Proteína Número OMIM™:
Humano CDKN1A 1026 6p21.2 NM_000389, NM_078467 NP_000380
 116899
Humano CDKN1B 1027 12p13.1 NM_004064 P46527
 610755
Ratón Cdkn1a 12575 17 A3.3 NM_001111099, NM_007669 P39689
 No Disponible
Ratón Cdkn1b 12576 6 G1 NM_009875 P46414
 No Disponible
 

It is now well established that cyclins play a positive role in promoting cell cycle transitions via their ability to associate with and activate their cognate cyclin-dependent kinases (Cdks). Cdk2 associates with cyclins A, D and E, and has been implicated in the control of the G1 to S phase transition in mammals. A novel Cdk-interacting protein, designated p21, Cip1 or WAF1, has been identified in cyclin A, cyclin D1, cyclin E and Cdk2 immunoprecipitates. p21 is a potent, tight-binding inhibitor of Cdks and can inhibit the phosphorylation of Rb by cyclin A-Cdk 2, cyclin E-Cdk2, cyclin D1-Cdk4 and cyclin D2-Cdk4 complexes. Expression of p21 is inducible by wildtype, but not mutant, p53. The mouse homolog of p21 is designated CAP20.

p21 Antibody (F-8) Menciones del Producto
Vea como otros han usado anticuerpos %catalog_number% y/o anticuerpos conjugados p21 (F-8).


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p21 Antibody (F-8) Data
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sc-271610
p21 (F-8): sc-271610. Western blot analysis of p21 expression in non-transfected 293T: sc-117752 (A), mouse p21 transfected 293T: sc-122305 (B) and C32 (C) whole cell lysates.
sc-271610
p21 (F-8): sc-271610. Western blot analysis of p21 expression in HeLa (A) and Cdc7/Cdk9 Inhibitor (sc-311303) treated HeLa (B) whole cell lysates.
sc-271610
p21 (F-8): sc-271610. Western blot analysis of p21 expression in untreated (A) and Doxorubicin HCl (Adriamycin) (sc-200923) treated (B) HCT 116 whole cell lysates. Note upregulation of p21 expression in lane B.
sc-271610
p21 (F-8): sc-271610. Western blot analysis of p21 expression in untreated (A) and Tenovin-1 (sc-222342) treated (B) MCF7 whole cell lysates. Note upregulation of p21 expression in lane B.
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