ALB/Albumin Antibody (F-10): sc-271605

ALB Antibody (F-10) is a mouse monoclonal IgG1 kappa light chain antibody developed to recognize amino acids 39-164 near the N-terminus of human serum albumin (ALB), also known as human serum albumin (HSA) or simply albumin. Anti-ALB antibody (F-10) is recommended for use in western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA) applications across mouse, rat, and human species. Serum albumin is the most abundant protein in blood plasma, synthesized in the liver, and plays a crucial role in maintaining the colloidal osmotic pressure of blood, which is essential for regulating fluid balance between blood vessels and tissues. Additionally, serum albumin functions as a carrier protein, binding and transporting a wide range of ligands including water, fatty acids, calcium, sodium, bilirubin, hormones, potassium, and various drugs, thereby facilitating their distribution and availability throughout the body. The ability of serum albumin to bind these molecules is vital for metabolic regulation and homeostasis, ensuring that essential substances are delivered to where they are needed while also aiding in the removal of waste products. Post-translational modifications of serum albumin, such as glycation and oxidation, enhance binding capacity and stability, allowing effective performance of transport and regulatory functions under diverse physiological conditions. Furthermore, serum albumin′s interaction with other proteins, such as fatty acid-binding proteins and the neonatal Fc receptor, is important for recycling and prolonged half-life in circulation. Mutations in the ALB gene can lead to disorders like familial dysalbuminemic hyperthyroxinemia (FDH), which affects thyroid hormone binding and underscores the clinical significance of serum albumin′s functional interactions. ALB monoclonal antibody (F-10) is an indispensable tool for advancing biomedical research and diagnostic applications, enabling a comprehensive understanding of albumin′s essential roles in health and disease.

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ALB/Albumin Antibody (F-10) References:

1. Albuminuria and cardiovascular risk in hypertensive patients with left ventricular hypertrophy: the LIFE study.  |  Wachtell, K., et al. 2003. Ann Intern Med. 139: 901-6. PMID: 14644892
2. The degree of albuminuria is related to left ventricular hypertrophy in hypertensive diabetics and is associated with abnormal left ventricular filling: a pilot study.  |  Salmasi, AM., et al. 2003. Angiology. 54: 671-8. PMID: 14666955
3. The recombinant subdomain IIIB of human serum albumin displays activity of gonadotrophin surge-attenuating factor.  |  Tavoulari, S., et al. 2004. Hum Reprod. 19: 849-58. PMID: 15016777
4. Tyrosine nitration in plasma proteins from patients undergoing hemodialysis.  |  Mitrogianni, Z., et al. 2004. Am J Kidney Dis. 44: 286-92. PMID: 15264187
5. Human albumin solution for resuscitation and volume expansion in critically ill patients.  |  Alderson, P., et al. 2004. Cochrane Database Syst Rev. CD001208. PMID: 15495011
6. Human albumin meta-analysis.  |  Seppelt, I. and Burrell, A. 2005. Crit Care Med. 33: 914-5; author reply 915-7. PMID: 15818134
7. The characteristics of monoclonal antibodies against human albumin.  |  Angelisová, P., et al. 1986. Folia Biol (Praha). 32: 289-94. PMID: 3506524
8. Familial dysalbuminemic hyperthyroxinemia: a syndrome that can be confused with thyrotoxicosis.  |  Ruiz, M., et al. 1982. N Engl J Med. 306: 635-9. PMID: 6173750
9. Screening and management of microalbuminuria in patients with diabetes mellitus: recommendations to the Scientific Advisory Board of the National Kidney Foundation from an ad hoc committee of the Council on Diabetes Mellitus of the National Kidney Foundation.  |  Bennett, PH., et al. 1995. Am J Kidney Dis. 25: 107-12. PMID: 7810516

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ALB/Albumin Antibody (F-10) has 55 citations in a variety of scientific publications.

Primary antibodies like Anti-ALB/Albumin Antibody (F-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ALB/Albumin Antibody (F-10) Specifications

Alternate Product Name: ALB

Product Clone Name: F-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 39-164

Epitope Target: serum albumin

Epitope Species: human

Product Reactivity/Detection: ALB

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 55 citations in various scientific publications

Available Conjugates/Forms for ALB/Albumin Antibody (F-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin