Calpain 5 Anticuerpo(A-5): sc-271271

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Calpains are calcium-activated thiol proteases involved in intracellular processing of proteins and signal transduction. The classic calpains are hetero-dimers with one large subunit, one small subunit and five EF-hand-calcium binding structures. The large subunit varies between family members and can be active without the small subunit. Calpain 5, sometimes referred to as HTRA3, belongs to the non-classical calpain subfamily that lacks the EF-hand-calcium-binding structures. Calpain 5 is ubiquitously expressed, localizes to the cytoplasm and nucleus and is a homolog of Calpain 10. Calpain 5, in addition to Calpain 10 and Calpain 6, differs from other subfamily members by the presence of a T-domain that is homologous to the Caenorhabditis elegans protein Tra-3. Calpain 5, the human ortholog of this nematode protein, may play a role in sex determination.