Abi-1 Anticuerpo(B-12): sc-271180

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The Abelson oncogene was initially identified as the viral transforming component of Abelson murine leukemia virus (A-MuLV). The Abelson gene (ABL1) encodes a SH2-domain bearing tyrosine kinase which conducts mitogenic signaling pursuant to growth factor receptor ligation. The Abl interactor proteins, Abi-1 and Abi-2, are SH3-domain containing proteins that bind to the proline-rich motifs of Abl and activate the kinase function. Two splice variants of Abi-1 are widely expressed, with the highest levels found in bone marrow, spleen, brain and testis. Abi-1 and Abi-2 are thought to negatively regulate cell growth and transformation, including cellular transformation through v-Abl. ABI1, the gene encoding Abi-1, has been shown to translocate and fuse with MLL (mixed lineage leukemia) gene in some cases of acute myeloid leukemia (AML). The Abi proteins have also been identified as mediators of cell motility by regulating Actin polymerization in lamellipodia and filopodia.