ΔN p73 Anticuerpo(N-16): sc-23429

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The human TP73 gene generates an amino-terminally truncated isoform called ?N p73. ?N p73 derives from an alternative promoter in intron 3 and lacks the transactivation domain of full-length TAp73. It is frequently overexpressed in a variety of human cancers, but not in normal tissues. ?N p73 acts as a potent transdominant inhibitor of wildtype p53 and transactivation-competent TAp73. It efficiently counteracts transactivation function, apoptosis and growth suppression mediated by wildtype p53 and TAp73, and confers drug resistance to wildtype p53 harboring tumor cells. Conversely, downregulation of endogenous ?N p73 levels by antisense methods alleviates its suppressive action and enhances p53- and TAp73-mediated apoptosis. Accumulation of ?N p73? induces drug resistance and alteration of apoptosis in human Cytomegalo-virus. In addition, methylation is involved in the control of ?N p73 expression in neuroblastoma.