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15-Lipoxygenase Inhibitor I (CAS 928853-86-5)

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Sinónimo:4-​methyl-​2-​(4-​methylpiperazinyl)pyrimido[4,​5-​b]benzothiazine
Solicitud:An inhibitor of 15-LO (15-lipoxygenase)
Número CAS:928853-86-5
Pureza:≥98%
Peso Molecular:313.4
Fórmula Molecular:C16H19N5S
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Nombre del productoNúmero de catálogoUnidadPrecioCantidadAñadir 
15-Lipoxygenase Inhibitor I sc-220625 500 µg $33
15-Lipoxygenase Inhibitor I sc-220625A 1 mg $63
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
Descripción
15-Lipoxygenase Inhibitor I is a heterocyclic pyrimidobenzothiazine compound which inhibits 15-LO with an IC50 value of 18 μM. Studies indicate that 15-Lipoxygenase has biological significance as a mediator of inflammation, thrombosis, and cancer via the oxidation products of the enzyme. It is believed that 15-Lipoxygenase Inhibitor I functions as an inhibitor by interfering with the redox cycle of 15-Lipoxygenase. Furthermore, 15-Lipoxygenase Inhibitor I acts as a catalyzing agent in the oxidation of polyunsaturated fatty acids.
Información Técnica
Estado Físico:Liquid
Almacenamiento:Store at -20° C
Seguridad e Información de Referencia
Transporte:UN 1888, Class 6.1, Packing group III
ID en PubChem:44423602
SMILES:CC1=C2C(=NC(=N1)N3CCN(CC3)C)SC4=CC=CC=C4N2
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
References
1. Chanez, P., et al. 2002. Am. J. Respir. Cell Mol. Biol. 27: 655-658. PMID: 12444024
2. Bakavoli, M., et al. 2007. Bioorg. Med. Chem. 15: 2120-2126. PMID: 17210254
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