Laminin β-2 Anticuerpo(H-300): sc-20777

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The laminins comprise a growing family of disulfide-linked heterotrimers consisting of three genetically distinct polypeptide chains, designated å, ∫ and ©. A major component of the basal lamina, laminins play a crucial role in providing a scaffolding upon which tissues are assembled and which serves as a physical barrier separating specialized tissues. During embryogenesis and early development, cells migrate along basement membranes, which are required for the polarization of cells. The ∫-2 Laminin chain plays a role in melanoma spread, promoting tumor migration along the abluminal surface of a vessel, a phenomenon which has been termed extra-vascular migratory metastasis.