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SKM 4-45-1 (CAS 290374-09-3)

Solicitud:A labeled analog of arachidonoyl ethanolamide
Número CAS:290374-09-3
Peso Molecular:804.9
Fórmula Molecular:C47H52N2O10
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 Información sobre pedidos
Nombre del productoNúmero de catálogoUnidadPrecioCantidadAñadir 
SKM 4-45-1 sc-205509 100 µg $56
SKM 4-45-1 sc-205509A 500 µg $255
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
Descripción
The cellular trafficking of arachidonoyl ethanolamide (anandamide; AEA) by neurons is dominated by hydrolysis and/or transport by fatty acyl amide hydrolase (FAAH) within the neurons.1 SKM 4-45-1 is a labeled analog of AEA that is non-fluorescent when outside the cell. Upon transport into the cell interior, it is cleaved by esterases to give a bright fluorescence at 530 nm. SKM 4-45-1 uptake into C6 glioma cells is inhibited by AEA and its analogs, and conversely SKM 4-45-1 inhibits the uptake of tritiated AEA, indicating that they compete for the AEA transporter.
Información Técnica
Apariencia:A solution in methyl acetate
Solubilidad:Soluble in ethanol, DMSO, methyl acetate and dimethyl formamide.
Almacenamiento:Store at -20° C
Seguridad e Información de Referencia
Transporte:UN 1231, Class 3, Packing group II
SMILES:CCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCCOC(=O)NC1CCC2C(C1)C(=O)OC12C2CCC(OC(=O) C)CC2OC2CC(CCC12)​OC(=O)​C
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
References
1 Deutsch, D.G., Glaser, S.T., Howell, J.M., et al. The cellular uptake of anandamide is coupled to its breakdown by fatty-acid amide hydrolase. J Biol Chem 276(10) 6967-6973 (2001). 2 Muthian, S., Nithipatikom, K., Campbell, W.B., et al. Synthesis and characterization of a fluorescent substrate for the N-arachidonoylethanolamine (anandamide) transmembrane carrier. J Pharmacol Exp Ther 293 289-295 (2000).
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