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Imidazole (CAS 288-32-4)

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Solicitud:A buffer useful in the pH range of 6.2-7.8
Número CAS:288-32-4
Pureza:≥99%
Peso Molecular:68.1
Fórmula Molecular:C3H4N2
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Nombre del productoNúmero de catálogoUnidadPrecioCantidadAñadir 
Imidazole sc-204776 25 g $16
Imidazole sc-204776A 100 g $44
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
Descripción
Imidazole is useful as a buffer in the pH range of 6.2-7.8 One of the applications of imidazole is in the purification of His-tagged proteins in immobilised metal affinity chromatography(IMAC). Imidazole is used to elute tagged proteins bound to Ni ions attached to the surface of beads in the chromatography column. An excess of imidazole is passed through the column, which displaces the His-tag from nickel co-ordination, freeing the His-tagged proteins. Imidazole has become an important part of many pharmaceuticals. Synthetic imidazoles are present in many fungicides and antifungal, antiprotozoal, and antihypertensive medications. Imidazole is part of the theophylline molecule, found in tea leaves and coffee beans, which stimulates the central nervous system. It is present in the anticancer medication mercaptopurine, which combats leukemia by interfering with DNA activities.
Información Técnica
Apariencia:White
Estado Físico:Solid
Solubilidad:Soluble in water (633 g/L) at 20 °C, acetone, chloroform, pyridine, alcohol, ether. Slightly soluble in benzene. Very slightly soluble in petroleum ether.
Almacenamiento:Store at room temperature
Punto de Fusión:87-92 °C
Punto de Ebullición:256 °C
Densidad:1.03 g/cm3 at 20 °C
Índice de Refracción:n20D 1.53
IC50:Nitric oxide synthase, inducible: IC50 = 40 µM (Mus musculus); Thromboxane-A synthase: IC50 = 670 µM (human)
Ki Data:Nitric-oxide synthase, brain: Ki= 175 µM (human)
Seguridad e Información de Referencia
Transporte:UN 3263, Class 8, Packing group III
WGK Alemania:1
RTECS:NI3325000
ID en PubChem:795
Índice Merck:14: 4912
Número MDL:MFCD00005183
Número EC:206-019-2
Registro Beilstein:103853
SMILES:N1C=CN=C1
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
References
Storrie, B., et al. (1990). Meth. Enzymol. 182, 217.
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