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Diosmin (CAS 520-27-4)

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Sinónimo:3’,5,7-Trihydroxy-4’-methoxyflavone 7-rutinoside
Solicitud:A flavonoid glycoside that reduces venous hyperpressure
Número CAS:520-27-4
Peso Molecular:608.5
Fórmula Molecular:C28H32O15
Refer to Certificate of Analysis for lot specific data (including water content).
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Nombre del productoNúmero de catálogoUnidadPrecioCantidadAñadirFavoritos
Diosmin sc-204728 5 g $33
Diosmin sc-204728A 25 g $98
Diosmin is an anti-inflammatory and a flavonoid glycoside that reduces venous hyperpressure. Diosmin also reduces capillary hyperpermeability and expression of endothelial adhesion molecules (ICAM1, VCAM1). Diosmin effectively inhibits the P-glycoprotein (Pgp)-mediated efflux in cells.
Información Técnica
Estado Físico:Solid
Solubilidad:Soluble in DMSO (50 mg/ml), water (122 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C).
Almacenamiento:Store at 4° C
Punto de Fusión:274 °C (dec.)
Punto de Ebullición:~926.8 °C at 760 mmHg (Predicted)
Densidad:~1.7 g/cm3 (Predicted)
Índice de Refracción:n20D 1.71 (Predicted)
Actividad Óptica:α20/D -121º±5º, c = 0.5 in 0.1 mol/l NaOH
Valores de pK:pKa: 6.1 (Predicted)
Seguridad e Información de Referencia
WGK Alemania:3
ID en PubChem:5281613
Índice Merck:14: 3297
Número MDL:MFCD00009772
Número EC:208-289-7
SMILES:C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC[C@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)OC 3=CC(=C4C(=C3)OC(=CC4=O)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
Clinical trial of oral diosmin (Daflon) in the treatment of hemorrhoids: W. Thanapongsathorn & T. Vajrabukka; Dis. Colon Rectum 35, 1085 (1992) Amine uptake inhibition by diosmin and diosmetin in human neuronal and neuroendocrine cell lines: E. Sher, et al.; Pharmacol. Res. 26, 395 (1992) Antioxidant activity of micronized diosmin on oxygen species from stimulated human neutrophils: B. Cypriani, et al.; Biochem. Pharmacol. 45, 1531 (1993) Diosmin-induced increase in sensitivity to Ca2+ of the smooth muscle contractile apparatus in the rat isolated femoral vein: J.P. Savineau & R. Marthan; Br. J. Pharmacol. 111, 978 (1994) Venous elasticity after treatment with Daflon 500 mg: V. Ibegbuna, et al.; Angiology 48, 45 (1997) Chemopreventive effects of diosmin and hesperidin on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary-bladder carcinogenesis in male ICR mice: M. Yang, et al.; Int. J. Cancer 73, 719 (1997) Diosmin and diosmetin are agonists of the aryl hydrocarbon receptor that differentially affect cytochrome P450 1A1 activity: H.P. Ciolino, et al.; Cancer Res. 58, 2754 (1998) Modulation by phytochemicals of cytochrome P450-linked enzyme activity: R.W. Teel & H. Huynh; Cancer Lett. 133, 135 (1998) Inhibition of lipopolysaccharide (LPS)-induced endothelial cytotoxicity by diosmin: M.F. Melzig & R. Loose; Pharmazie 54, 298 (1999) Anti-inflammatory activity of diosmin and hesperidin in rat colitis induced by TNBS: M.E. Crespo, et al.; Planta Med. 65, 651 (1999) Further investigation of the modifying effect of various chemopreventive agents on apoptosis and cell proliferation in human colon cancer cells: Q. Zheng, et al.; J. Cancer Res. Clin. Oncol. 128, 539 (2002) The effect of diosmin hesperidin on intestinal ischaemia--reperfusion injury: M. Pehlivan, et al.; Acta Chir. Belg. 104, 715 (2004) Treatment of metastatic melanoma B16F10 by the flavonoids tangeretin, rutin, and diosmin: C. Martinez Conesa, et al.; J. Agric. Food Chem. 53, 6791 (2005)
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