Kendomycin (CAS 183202-73-5)

Kendomycin is a polyketide macrolide antibiotic isolated from various Streptomyces strains, with demonstrated cytotoxic and antiosteoporotic properties. Structurally intriguing to synthetic chemists, the macrocycle of Kendomycin contains a rare quinone methide chromophore. The antibiotic activity of Kendomycin shows efficacy against a range of bacteria including Methicillin- and Vancomycin-resistant Staphylococcus aureus. Studies correlate the demonstrated cytotoxicity of Kendomycin against multiple tumor cell lines to an inhibition of chymotrypsin-like proteasome activity. Kendomycin is also described to disable the antiapoptotic protein Bcl-xl by blocking protein-protein interaction with Bak, though this finding showed no direct correlation to cytotoxicity. Early reports described Kendomycin as an endothelin receptor antagonist, and the antiosteoporotic effects were correlated to calcitonin receptor agonism.

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