Enniatin B (CAS 917-13-5)

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Solicitud:	An ionophore antibiotic that inhibits Pdr5p
Número CAS:	917-13-5
Pureza:	90% (HPLC)
Peso Molecular:	639.8
Fórmula Molecular:	C₃₃H₅₇N₃O₉

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Descripción

Enniatin B is an ionophore antibiotic and fungal metabolite generated by multiple Fusarium strains. Studies indicate that Enniatin B has cytotoxic activity in vitro and no genotoxic activity. The Pdr5p ABC transporter in Saccharomyces cerevisiae has been shown to be inhibited by Enniating B, with less toxicity than FK506. Valinomycin (sc-200991) and Enniatin B studies have demonstrated that they can bind to calmodulin (CaM) and inhibit the activity of 3',5'-cyclic nucleotide phosphodiesterase (PDE).

Información Técnica

Apariencia:	White to off-white
Estado Físico:	Solid
Derivado de:	Fusarium sp.
Solubilidad:	Soluble in DMSO or other organic solvents; almost insoluble in water.
Almacenamiento:	Store at -20° C

Seguridad e Información de Referencia

Transporte:	UN 3462, Class 6.1, Packing group II
SMILES:	CC(C)C1C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N1C)C(C)C)C(C)C)C)C(C) C)C(C)C)C)C(C)C

Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.

References

1. Lifson, S., et al. 1984. J. Biomol. Struct. Dyn. 2: 641-661. PMID: 6400917
2. Mereish, K.A., et al. 1990. Pept. Res. 3: 233-237. PMID: 1724618
3. Hiraga, K., et al. 2005. Biochem. Biophys. Res. Commun. 328: 1119-1125. PMID: 15707993
4. Dornetshuber, R., et al. 2007. Chem. Res. Toxicol. 20: 465-473. PMID: 17326668
5. Behm, C., et al. 2009. Mol Nutr Food Res. 53: 423-430. PMID: 19360736

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