Dihydroavermectin B1b (CAS 70209-81-3)

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Solicitud:	A nematocidal reagent
Número CAS:	70209-81-3
Pureza:	>99%
Peso Molecular:	861.1
Fórmula Molecular:	C₄₇H₇₂O₁₄

This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.

Descripción

Dihydroavermectin B1b is the minor component (>20%) of the anthelmintic, ivermectin (sc-203609). Members of this class are believed to exert their anthelmintic effects by binding to glutamate-gated chloride channels expressed on nematode neurons and pharyngeal muscle cells. In vitro tests have found the B1b (25-iso-propyl) analogue to be slightly more potent than the 25-sec-butyl (B1a) analogue as an inhibitor of nematode larval development and paralysis and also a more sensitive probe for ivermectin resistance.

Información Técnica

Apariencia:	White
Estado Físico:	Solid
Derivado de:	Streptomyces avermitlis
Solubilidad:	Soluble in ethanol, methanol, DMF or DMSO.
Almacenamiento:	Store at -20° C

Seguridad e Información de Referencia

Transporte:	UN 2588, Class 6.1, Packing group II
ID en PubChem:	6321425
SMILES:	CC1CCC2(CC3CC(O2)CC=C(C(C(C=CC=C4COC5C4(C(C=C(C5O)C)C(=O)O3)O)C)OC6CC(C(C(O6 )C)OC7CC(C(C(O7)C)O)OC)OC)C)OC1C(C)C

Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.

References

1. Chabala, J.C., et al. 1980. J. Med. Chem. 23: 1134-1136. PMID: 6893469
2. Campbell, W.C., et al. 1983. Science. 221: 823-828. PMID: 6308762
3. Gill, J.H. and Lacey, E. 1998. Int. J. Parasitol. 28: 863-877. PMID: 9673866
4. Wolstenholme, A.J. and Rogers, A.T. 2005. Parasitology. 131: S85-S95. PMID: 16569295

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BIOQUIMICOS

Por General Research Use:

Insecticidal Reagents