Molecular structure of RGD peptide (GRGDNP), CAS Number: 114681-65-1
RGD peptide (GRGDNP) (CAS 114681-65-1)
See product citations (13)
Application:
RGD peptide (GRGDNP) is an inhibitor of integrin-ligand interactions
CAS Number:
114681-65-1
Purity:
≥97%
Molecular Weight:
614.61
Molecular Formula:
C23H38N10O10
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
RGD peptide (GRGDNP) acts as an inhibitor of integrin-ligand interactions and can induce apoptosis in the absence of signals and integrin-mediated cell clustering. Research demonstrates that RGD peptide (GRGDNP) promote apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. The RGD peptide (GRGDNP) can serve as a cell adhesion site of extracellular matrix, cell surface proteins, and integrins. In addition, it can inhibit ACK-2 activation through cell adhesion.
RGD peptide (GRGDNP) (CAS 114681-65-1) References
- RGD peptides induce apoptosis by direct caspase-3 activation. | Buckley, CD., et al. 1999. Nature. 397: 534-9. PMID: 10028971
- Activation of the Cdc42-associated tyrosine kinase-2 (ACK-2) by cell adhesion via integrin beta1. | Yang, W., et al. 1999. J Biol Chem. 274: 8524-30. PMID: 10085085
- Integrin signaling, free radicals, and tyrosine kinase mediate flow constriction in isolated cerebral arteries. | Madden, JA. and Christman, NJ. 1999. Am J Physiol. 277: H2264-71. PMID: 10600845
- alpha(v)beta(3) Integrin interacts with the transforming growth factor beta (TGFbeta) type II receptor to potentiate the proliferative effects of TGFbeta1 in living human lung fibroblasts. | Scaffidi, AK., et al. 2004. J Biol Chem. 279: 37726-33. PMID: 15187087
- Mechanotransduction by integrin is essential for IL-6 secretion from endothelial cells in response to uniaxial continuous stretch. | Sasamoto, A., et al. 2005. Am J Physiol Cell Physiol. 288: C1012-22. PMID: 15613495
- RGD-peptide presents anti-adhesive effect, but not direct pro-apoptotic effect on endothelial progenitor cells. | Kim, SY., et al. 2007. Arch Biochem Biophys. 459: 40-9. PMID: 17224123
- Integrins, adhesion and apoptosis. | Meredith, JE. and Schwartz, MA. 1997. Trends Cell Biol. 7: 146-50. PMID: 17708932
- Plasminogen activator inhibitor-1 regulates integrin alphavbeta3 expression and autocrine transforming growth factor beta signaling. | Pedroja, BS., et al. 2009. J Biol Chem. 284: 20708-17. PMID: 19487690
- Compensatory endocytosis in bladder umbrella cells occurs through an integrin-regulated and RhoA- and dynamin-dependent pathway. | Khandelwal, P., et al. 2010. EMBO J. 29: 1961-75. PMID: 20461056
- Stretch and inflammation-induced Pre-B cell colony-enhancing factor (PBEF/Visfatin) and Interleukin-8 in amniotic epithelial cells. | Kendal-Wright, CE., et al. 2010. Placenta. 31: 665-74. PMID: 20598369
- PAI-1-regulated miR-21 defines a novel age-associated fibrogenic pathway in muscular dystrophy. | Ardite, E., et al. 2012. J Cell Biol. 196: 163-75. PMID: 22213800
- OmpA-mediated rickettsial adherence to and invasion of human endothelial cells is dependent upon interaction with α2β1 integrin. | Hillman, RD., et al. 2013. Cell Microbiol. 15: 727-41. PMID: 23145974
- RGD and other recognition sequences for integrins. | Ruoslahti, E. 1996. Annu Rev Cell Dev Biol. 12: 697-715. PMID: 8970741
- Role of ICAM-1 and ICAM-2 and alternate CD11/CD18 ligands in neutrophil transendothelial migration. | Issekutz, AC., et al. 1999. J Leukoc Biol. 65: 117-26. PMID: 9886254
Inhibitor of:
Integrin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RGD peptide (GRGDNP), 5 mg | sc-201176 | 5 mg | $203.00 |