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MDL-72222 (CAS 40796-97-2)

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Sinónimo:Bemesetron
Solicitud:A potent and highly selective antagonist at neuronal 5-hydroxytryptamine receptors
Número CAS:40796-97-2
Pureza:99%
Peso Molecular:314.2
Fórmula Molecular:C15H17Cl2NO2
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MDL-72222 sc-201132 50 mg $167
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
Descripción
MDL-72222 is a potent and highly selective antagonist at certain excitatory 5-hydroxytryptamine receptors on mammalian peripheral neurons. MDL-72222 is most often used to study the role of SR-3. Studies suggest the blockade of SR-3 with MDL 72222 may ameliorate beta-amyloid protein-induced neurotoxicity by interfering with the increase of Ca2+, and then by inhibiting glutamate release, generation of reactive oxygen species and caspase-3 activity. MDL-72222 is also used in the study of dopamine elevation in rats due to cocaine and amphetamine consumption.
Información Técnica
Apariencia:White
Estado Físico:Solid
Solubilidad:Soluble in DMSO (100 mM), 0.1 M HCl (slightly soluble), chloroform, and ethanol (sparingly soluble). Insoluble in water.
Almacenamiento:Store at room temperature
Punto de Fusión:80-90 °C
Punto de Ebullición:406.51 °C at 760 mmHg (Predicted)
Densidad:1.34 g/cm3 (Predicted)
Índice de Refracción:n20D 1.60 (Predicted)
IC50:Adenosine A3 receptor: IC50 = 9.3 nM (human); Serotonin 3a receptor: IC50 = 9.4 nM (human); Serotonin 3a receptor: IC50 = 42.6 nM (Rattus norvegicus); Serotonin 3b receptor: IC50 = 42.6 nM (Rattus norvegicus)
Ki Data:Serotonin 3a receptor: Ki= 3.9 nM (human); Serotonin 3b receptor: Ki= 10 nM (human); Serotonin 3c receptor: Ki= 10 nM (human); Serotonin 3d receptor: Ki= 10 nM (human); Serotonin 3e receptor: Ki= 10 nM (human)
Seguridad e Información de Referencia
Transporte:UN 2811, Class 6.1, Packing group III
WGK Alemania:3
RTECS:DG7580000
ID en PubChem:1683
Número MDL:MFCD00078562
SMILES:CN1C2CCC1CC(C2)OC(=O)C3=CC(=CC(=C3)Cl)Cl
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
References
1. Fozard, J.R. 1984. Naunyn Schmiedebergs Arch. Pharmacol. 326: 36-44. PMID: 6472484
2. Kankaanpää, A., et al. 1996. Pharmacol. Toxicol. 78: 317-321. PMID: 8737967
3. Frankel, P.S., et al. 1998. Brain Res. 814: 186-193. PMID: 9838105
4. Ju Yeon Ban, et al. 2005. Eur. J. Pharmacol. 520: 12-21. PMID: 16150439
5. Yoo, J.H., et al. 2008. Synapse. 62: 8-13. PMID: 17948891
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