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NS-398 (CAS 123653-11-2)

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Solicitud:A selective Cox-2 inhibitor neuroprotective agent
Número CAS:123653-11-2
Pureza:98%
Peso Molecular:314.35
Fórmula Molecular:C13H18N2O5S
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Nombre del productoNúmero de catálogoUnidadPrecioCantidadAñadir 
NS-398 sc-200604 5 mg $82
NS-398 sc-200604A 25 mg $325
Descripción
NS-398 is a small molecule inhibitor of Cox (cyclooxygenase), relatively selective for Cox-2 (IC50 of 3.8 μM) over Cox-1 (IC50 of > 100 μM). The inflammatory response to injury and stimulus is associated with Cox-2 activity, and this activity is thought to be related to neurotoxicity presented in the progression of cerebral ischemia. NS-398 intervenes upon this progression through inhibition of Cox-2, potentially by suppressing the synthesis of Cox-2 reaction products such as prostanoids and superoxide radicals. Additionally, NS-398 is shown to reduce the extent of neuronal damage caused by glutamate excitotoxicity and by N-methyl-D-aspartate injection through blocking the Cox-2 response. Another report assessing Cox-2-mediated neuronal damage associated with methamphetamine further indicates that reactive oxygen species generated by Cox-2 are culprit in this process, rather than prostaglandin expression strongly associated with Cox enzymes and the inflammatory response.
Información Técnica
Apariencia:Off-white
Estado Físico:Solid
Solubilidad:Soluble in a 1:3 solution of DMSO:PBS(pH7.2) (~400 µg/ml), DMF (~30 mg/ml), DMSO (25 mg/ml), a 2:3 solution of DMSO:PBS (pH 7.2) (2 mg/ml), ethanol(5mg/8ml warm), 100% ethanol (4 mg/ml), methanol, acetone, acetonitrile, and ethanol (0.5 m/ml). Insoluble in water.
Almacenamiento:Store at room temperature
Punto de Fusión:136-137 °C
Punto de Ebullición:490.65 °C at 760 mmHg
Densidad:1.38 g/cm3
Índice de Refracción:n20D 1.59
IC50:COX-2: IC50 = 3.8 µM (sheep placental); PGH synthase-2: IC50 = 1 µM; Cyclooxygenase-2 : IC50 = 1 nM (Homo sapiens ); COX-1: IC50 = 75 µM (human); COX-2: IC50 = 1.77 µM (human); COX-1: IC50 = 220 µM (ovine); COX-2: IC50 = 0.15 µM (ovine); Cyclooxygenase-2 : IC50 = <2 nM (Mus musculus ); Cyclooxygenase-2 : IC50 = 2600 nM (Ovis aries ); Cyclooxygenase-1 : IC50 = 1670 nM (Mus musculus ); Cyclooxygenase-1 : IC50 = 3000 nM (Homo sapiens ); RAW264.7 (Monocytic-macrophage leukemia cells) RAW264.7 (Monocytic-macrophage leukemia cells) : IC50 = 500 nM (Mus musculus )
Seguridad e Información de Referencia
WGK Alemania:3
RTECS:PB0473500
ID en PubChem:4553
Número MDL:MFCD00882995
SMILES:CS(=O)(=O)NC1=C(C=C(C=C1)[N+](=O)[O-])OC2CCCCC2
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
References
1. Araki, E., et al. 2001. Stroke. 32: 2370-2375. PMID: 11588328
2. Thomas, D.M., et al. 2005. J. Pharmacol. Exp. Ther. 313: 870-876. PMID: 15718289
NS-398 (CAS 123653-11-2) Menciones del Producto
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