Endomucin Anticuerpo(C-16): sc-19901

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Mucin-like membrane glycoproteins contain many serine and threonine residues, which carry large amounts of O-linked glycans, forcing the molecule into an extended structure. Endomucin, also known as EMCN or Mucin-14, is a 261 amino acid protein which contains a transmembrane sequence and multiple glycosylation sites. Human Endomucin, which is highly expressed in vascular tissues such as heart, kidney and lung, exists as both an unprocessed precursor peptide and as a 241 amino acid processed protein, known as Endomucin 2. Mouse Endomucin is an endothelial antigen found in venous endothelium, as well as capillaries, but not on arterial endothelium. Endomucin expression is increased while endothelial cells are proliferating or are stimulated by tumor-conditioned media or specific angiogenic factors such as bFGF (basic fibroblast growth factor) and TNFå. Overexpression of Endomucin inhibits adhesion and aggregation of hematopoietic cells, suggesting that Endomucin may play a role in detachment of hematopoietic cells from endothelium during early hematopoiesis.