Date published: 2026-8-8

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PD-L1 Antibodies

Santa Cruz Biotechnology features a diverse variety of PD-L1 monoclonal antibodies for various research applications. Programmed death-ligand 1 (PD-L1) monoclonal antibodies are optimized for techniques such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Programmed death-ligand 1 (PD-L1) plays a critical role in regulating immune responses by inhibiting T-cell activation and promoting immune tolerance. PD-L1 expression is often upregulated in tumors, making it a significant target for cancer immunotherapy. Understanding PD-L1 function and regulation is essential for developing effective treatments and improving patient outcomes in various malignancies. Researchers worldwide rely on PD-L1 monoclonal antibodies to explore immune checkpoint pathways and their impact on cancer development. Current investigations focus on how PD-L1 influences tumor microenvironment and immune system interactions. PD-L1 research continues to reveal new insights into cancer biology and potential therapeutic strategies. Santa Cruz Biotechnology monoclonal antibodies support researchers in advancing scientific knowledge and developing innovative cancer treatments.

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PD-L1 Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

CD274/PD-L1 Antibody (1C10)

sc-293425mouse IgG2b κ18-238 (h)WB, IP, ELISAh
14
(6)

CD274/PD-L1 Antibody (D-8)

sc-518027mouse IgG2b κ218-243 (h)WB, IP, IF, ELISAm, r, h
3
(1)

PD-L1 siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

CD274/PD-L1 siRNA (h)

sc-39699hGene SilencingN/A
11
(0)

CD274/PD-L1 shRNA Plasmid (h)

sc-39699-SHhGene SilencingPuromycin
11
(0)

CD274/PD-L1 shRNA (h) Lentiviral Particles

sc-39699-VhGene SilencingPuromycin
11
(0)

CD274/PD-L1 siRNA (m)

sc-39700mGene SilencingN/A
6
(0)

CD274/PD-L1 shRNA Plasmid (m)

sc-39700-SHmGene SilencingPuromycin
6
(0)

CD274/PD-L1 shRNA (m) Lentiviral Particles

sc-39700-VmGene SilencingPuromycin
6
(0)

PD-L1 CRISPR Knockout (KO) and HDR Plasmids

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

CD274/PD-L1 CRISPR/Cas9 KO Plasmid (h2)

sc-401140-KO-2Gene Knockouth0
(0)

CD274/PD-L1 HDR Plasmid (h2)

sc-401140-HDR-2Homology Directed Repairh0
(0)

CD274/PD-L1 CRISPR/Cas9 KO Plasmid (m)

sc-425636Gene Knockoutm0
(0)

CD274/PD-L1 HDR Plasmid (m)

sc-425636-HDRHomology Directed Repairm0
(0)

PD-L1 CRISPR Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

CD274/PD-L1 Double Nickase Plasmid (h)

sc-401140-NICGene Knockouth0
(0)

CD274/PD-L1 Double Nickase Plasmid (h2)

sc-401140-NIC-2Gene Knockouth0
(0)

CD274/PD-L1 Double Nickase Plasmid (m)

sc-425636-NICGene Knockoutm0
(0)

CD274/PD-L1 Double Nickase Plasmid (m2)

sc-425636-NIC-2Gene Knockoutm0
(0)

PD-L1 CRISPR Activation Plasmids and Lentiviral Particles

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

CD274/PD-L1 CRISPR Activation Plasmid (h)

sc-401140-ACTGene Activationh0
(0)

CD274/PD-L1 CRISPR Activation Plasmid (h2)

sc-401140-ACT-2Gene Activationh0
(0)

CD274/PD-L1 Lentiviral Activation Particles (h)

sc-401140-LACGene Activationh0
(0)

CD274/PD-L1 Lentiviral Activation Particles (h2)

sc-401140-LAC-2Gene Activationh0
(0)

CD274/PD-L1 CRISPR Activation Plasmid (m)

sc-425636-ACTGene Activationm0
(0)

CD274/PD-L1 Lentiviral Activation Particles (m)

sc-425636-LACGene Activationm0
(0)