p-CPI-17 Anticuerpo(Thr 38): sc-17560

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A phosphorylation-dependent inhibitory protein for smooth muscle myosin phosphate, CPI-17 was originally identified as a PKC-potentiated inhibitory protein of protein phosphatase-1, which is dominantly expressed in smooth muscle. Phosphorylation at Threonin 38, in vitro, by PKC or Rho-kinase enhances the inhibitory potency toward myosin phosphatase. CPI-17 is also phosphorylated at Threonine 38 by protein kinase N and might be involved in the calcium sensitization of smooth muscle contraction as a downstream effector of Rho and/or arachidonic acid. CPI-17 is dually phosphoryl-ated at Serine 12 and Threonine 38 by a MYPT-associated kinase, M110 kinase.