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p-Adducin Anticuerpo(Thr 445): sc-16738

 |  Ficha Técnica

(Basado en el análisis de datos)
  • p-Adducin Antibody (Thr 445) is a goat polyclonal IgG provided at 200 µg/ml; also available as rabbit IgG provided at 200 µg/ml, sc-16738-R
  • epitope corresponding to a short amino acid sequence containing phosphorylated Thr 445 of Adducin α of human origin
  • recommended for detection of Thr 445 phosphorylated Adducin α and correspondingly phosphorylated Thr 431 of Adducin β of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
  • blocking peptide, sc-16738 P
  • See 3 citations for p-Adducin Anticuerpo (Thr 445)
 

Ver tambiénAdducin AntibodiesincluyebdoAdducin, Adducin alpha, Adducin betayAdducin gamma.

Información sobre pedidosMenciones del ProductoInformación del gen
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 Información sobre pedidos
Nombre del productoNúmero de catálogoUnidadPrecioCantidadAñadir 
p-Adducin Antibody (Thr 445) sc-16738 200 µg/ml $279
p-Adducin (Thr 445) P sc-16738 P
(peptide)
 100 µg/0.5 ml $61
p-Adducin Antibody (Thr 445)-R sc-16738-R 200 µg/ml $279
 Lisado de células para control positivo de WB (Haga click en el nombre del producto para obtener más información)
Nombre del productoNúmero de catálogoUnidadPrecioCantidadAñadir 
Adducin α (m): 293T Lysate sc-118250 100 µg/200 µl $205
Adducin β (h2): 293T Lysate sc-117077 100 µg/200 µl $205
Adducin γ(m): 293T Lysate sc-118249 100 µg/200 µl $205
NIH/3T3 Whole Cell Lysate sc-2210 500 µg/200 µl $104
K-562 Whole Cell Lysate sc-2203 500 µg/200 µl $104
K-562 + PMA Cell Lysate sc-2280 500 µg/200 µl $104
 
Especies Nombre del Gen Gene ID Ubicación en el cromosoma Numero de Acceso de Isoforma (ARNm) Número de Acceso de la Proteína Número OMIM™:
Humano ADD1 118 4p16.3 NM_001119, NM_014189, NM_014190, NM_176801 P35611
 145500
Humano ADD2 119 2p13.3 NM_001617, NM_017482, NM_017483, NM_017484, NM_017488 P35612
 102681
Humano ADD3 120 10q25.1 NM_001121, NM_016824, NM_019903 Q9UEY8
 601568
Ratón Add3 27360 19 D2 Q9QYB5
 No Disponible
 

Adducins are a family of cytoskeleton proteins encoded by three genes (a, b and g). Adducin is a protein associated with the inner leaflet of the plasma membrane and is one of the proteins localized at the spectrin-actin junction of the membrane skeleton. Adducins promote association of spectrin with actin and cap the fast growing end of actin filaments. Adducins contain an N-terminal core, neck and C-terminal tail domains, are substrates for protein kinase A (PKA) and C (PKC), and bind to Ca2+/calmodulin. The major phosphorylation sites common to the Adducins are Ser 726 and Ser 713 in the C-terminal MARCKS-related domains of Adducin a and Adducin b, and they are phosphorylated by PKA and PKC, respectively. In addition, PKA phosphorylates Adducin a at Ser 408, 436 and 481. Calmodulin-binding is inhibited by phosphorylation of Adducin b that, in turn, inhibits the rate of phospho-rylation of Adducin b, but not Adducin a. Rho-kinase can phosphorylate Adducin a at Thr 445 and Thr 480 downstream of Rho in vivo. The phosphorylation of Adducin by Rho-kinase plays an important role in the regulation of membrane ruffling and cell motility. In addition, phosphorylation at Ser 726 of Adducin a is required for cleavage by caspase-3 .

p-Adducin Antibody (Thr 445) Menciones del Producto
Vea como otros han usado anticuerpos %catalog_number% y/o anticuerpos conjugados p-Adducin (Thr 445).


3 menciones totales
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