CALHM2 Anticuerpo(E-12): sc-167376

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The level of intracellular calcium is tightly regulated in all eukaryotic cells. A modest increase in this level can result in a myriad of physiological responses, most of which are mediated by calmodulin (CaM), the universal calcium sensor. CALHM2 (Calcium homeostasis modulator protein 2), also known as FAM26B, is a 323 amino acid multi-pass membrane protein that may be involved in the modulation of calcium signaling stemming from bitter, sweet and umami receptor activation in taste buds. Unlike CALHM1, it is not likely that CALHM2 plays a role in the pathogenesis of Alzheimer’s Disease. There are three isoforms of CALHM2 that are produced as a result of alternative splicing events. The gene encoding CALHM2 maps to human chromosome 10, which contains over 800 genes and 135 million nucleotides, making up nearly 4.5% of the human genome.