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p-Adducin Anticuerpo(Ser 726): sc-16736

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(Basado en el análisis de datos)

  • p-Adducin Antibody (Ser 726) is a goat polyclonal IgG provided at 200 µg/ml; also available as rabbit IgG provided at 200 µg/ml, sc-16736-R
  • recommended for detection of Ser 726 phosphorylated Adducin α and correspondingly phosphorylated Adducin β and Adducin γ of mouse, rat and human origin by WB, IP and IF; also reactive with additional species, including equine, canine, bovine, porcine and avian
  • blocking peptide, sc-16736 P
  • See 4 citations for p-Adducin Anticuerpo (Ser 726)
 

Ver tambiénAdducin AntibodiesincluyebdoAdducin, Adducin alpha, Adducin betayAdducin gamma.

Información sobre pedidosMenciones del ProductoInformación del gen
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WB   IP   IF  
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 Información sobre pedidos
Nombre del productoNúmero de catálogoUnidadPrecioCantidadAñadir 
p-Adducin Antibody (Ser 726) sc-16736 200 µg/ml $279
p-Adducin (Ser 726) P sc-16736 P
(peptide)
 100 µg/0.5 ml $61
p-Adducin Antibody (Ser 726)-R sc-16736-R 200 µg/ml $279
Lambda Phosphatase sc-200312 100000 units in 0.25 ml $462
Lambda Phosphatase sc-200312A 20000 units in 0.05 ml $116
Lambda Phosphatase sc-200312 100000 units in 0.25 ml $462
Lambda Phosphatase sc-200312A 20000 units in 0.05 ml $116
 Lisado de células para control positivo de WB (Haga click en el nombre del producto para obtener más información)
Nombre del productoNúmero de catálogoUnidadPrecioCantidadAñadir 
Adducin α (m): 293T Lysate sc-118250 100 µg/200 µl $205
Adducin β (h2): 293T Lysate sc-117077 100 µg/200 µl $205
Adducin γ(m): 293T Lysate sc-118249 100 µg/200 µl $205
NIH/3T3 Whole Cell Lysate sc-2210 500 µg/200 µl $104
K-562 Whole Cell Lysate sc-2203 500 µg/200 µl $104
K-562 + PMA Cell Lysate sc-2280 500 µg/200 µl $104
 
Especies Nombre del Gen Gene ID Ubicación en el cromosoma Numero de Acceso de Isoforma (ARNm) Número de Acceso de la Proteína Número OMIM™:
Humano ADD1 118 4p16.3 NM_001119, NM_014189, NM_014190, NM_176801 P35611
 145500
Humano ADD2 119 2p13.3 NM_001617, NM_017482, NM_017483, NM_017484, NM_017488 P35612
 102681
Humano ADD3 120 10q25.1 NM_001121, NM_016824, NM_019903 Q9UEY8
 601568
Ratón Add1 11518 5 B2 Q9QYC0
 No Disponible
Ratón Add2 11519 6 D1 Q9QYB8
 No Disponible
Ratón Add3 27360 19 D2 Q9QYB5
 No Disponible
 

Adducins are a family of cytoskeleton proteins encoded by three genes (a, b and g). Adducin is a protein associated with the inner leaflet of the plasma membrane and is one of the proteins localized at the spectrin-actin junction of the membrane skeleton. Adducins promote association of spectrin with actin and cap the fast growing end of actin filaments. Adducins contain an N-terminal core, neck and C-terminal tail domains, are substrates for protein kinase A (PKA) and C (PKC), and bind to Ca2+/calmodulin. The major phosphorylation sites common to the Adducins are Ser 726 and Ser 713 in the C-terminal MARCKS-related domains of Adducin a and Adducin b, and they are phosphorylated by PKA and PKC, respectively. In addition, PKA phosphorylates Adducin a at Ser 408, 436 and 481. Calmodulin-binding is inhibited by phosphorylation of Adducin b that, in turn, inhibits the rate of phospho-rylation of Adducin b, but not Adducin a. Rho-kinase can phosphorylate Adducin a at Thr 445 and Thr 480 downstream of Rho in vivo. The phosphorylation of Adducin by Rho-kinase plays an important role in the regulation of membrane ruffling and cell motility. In addition, phosphorylation at Ser 726 of Adducin a is required for cleavage by caspase-3 .

p-Adducin Antibody (Ser 726) Menciones del Producto
Vea como otros han usado anticuerpos %catalog_number% y/o anticuerpos conjugados p-Adducin (Ser 726).


4 menciones totales
Cargando las citaciones
 
p-Adducin Antibody (Ser 726) Data
Haga click en la imágen para agrandarla
sc-16736
p-Adducin (Ser 726)-R: sc-16736-R. Western blot analysis of phosphorylated Adducin expression in uninduced (A) and PMA-induced (B) K-562 whole cell lysates.
sc-16736
p-Adducin (Ser 726)-R: sc-16736-R. Immunofluorescence staining of methanol-fixed K-562 cells showing membrane localization.
sc-16736
p-Adducin (Ser 726)-R: sc-16736-R. Immunofluorescence staining of methanol-fixed K-562 cells showing cytoplasmic localization.
sc-16736
p-Adducin (Ser 726): sc-16736. Western blot analysis of Adducin α phosphorylation in non-transfected: sc-117752 (A) and mouse Adducin α transfected: sc-118250 (B) 293T whole cell lysates.
sc-16736
Western blot analysis of Adducin α phosphorylation in non-transfected: sc-117752 (A, D), untreated mouse Adducin α transfected: sc-118250 (B, E) and lambda protein phosphatase treated mouse Adducin α transfected: sc-118250 (C, F) 293T whole cell lysates. Antibodies tested include p-Adducin (Ser 726)-R: sc-16736-R (A, B, C) and Adducin α (4D1): sc-33633 (D, E, F).
sc-16736
Western blot analysis of Adducin phosphorylation in untreated (A,C) and lambda protein phosphatase (sc-200312A) treated (B,D) HL-60 whole cell lysates. Antibodies tested include p-Adducin (Ser 726)-R: sc-16736-R (A,B) and Adducin α (H-100): sc-25731 (C,D).
sc-16736
Western blot analysis of Adducin phosphorylation in untreated (A,C) and lambda protein phosphatase (sc-200312A) treated (B,D) rat brain tissue extracts. Antibodies tested include p-Adducin (Ser 726)-R: sc-16736-R (A,B) and Adducin α (H-100): sc-25731 (C,D).
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