PRMT1 Anticuerpo(B-2): sc-166963

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A class of proteins termed type 1 protein arginine N-methyltransferase (PRMTs) enzymes contribute to post-translational modification of RNA-binding proteins, but differ in substrate specificities, oligomerization properties, and subcellular localization. PRMT1, the predominant form in mammalian cells, is located in the nucleus. At the carboxy terminus, Interleukin enhancer-binding factor 3 (ILF3) binds PRMT1, thereby regulating PRMT1 activity. Alternative mRNA splicing of the PRMT gene results in three isoforms of PRMT1 that differ in their amino terminus regions, all of which are enzymatically active. PRMT8, also known as HRMT1L3 or HRMT1L4 (heterogenous nuclear ribonucleioprotein methyltransferase-like protein 4), is a distinct member of the type 1 PRMT family with tissue-specific expression and plasma membrane localization. PRMT8 is specifically expressed in the brain where it functions as an arginine methyltransferase with a possible role in neuronal differentiation. It is most closely related to PRMT1 and may have arisen through a gene duplication. PRMT8 can heterodimerize with PRMT1 and has similar substrate preference.