VPS28 Anticuerpo(E-7): sc-166537

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Vacuolar protein sorting protein 28 (VPS28) is required for normal endocytic and biosynthetic trafficking to the vacuole. VPS28 mutants accumulate vacuolar endocytic and late Golgi markers in an abberant endosome-like class E compartment. Class E compartments contain endocytosed markers, as well as precursors of vacuolar hydrolases and markers normally associated with the trans Golgi. VPS28 as well as other class E VPS proteins may facilitate the formation of transport intermediates required for efficient transport out of the prevacuolar endosome. Class E proteins appear to be important for sorting material bound for the vacuole away from proteins that cycle through the endocytic system. VPS28 of Saccharomyces cerevisiae and its human ortholog localize to the cytoplasm and can be found as subunits of a complex named ESCRT-1, endosomal sorting complex required for transport 1.