TAPP2 Anticuerpo(A-7): sc-166351

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Tandem PH (pleckstrin homology) domain-containing protein 2 (TAPP2) is a widely expressed cytoplasmic adaptor protein related to BAM32. Highest expression levels of TAPP2 are found in heart and kidney tissues. Upon growth factor stimulation and activation of phosphoinositol 3-kinase, TAPP2 is recruited to the plasma membrane and accumulates in F-Actin-rich membrane ruffles. This recruitment occurs through the specific interaction of the TAPP2 C-terminal PH domain with phosphotidylinositol 3,4-bisphosphate. TAPP2 is positively regulated by Fc g RII and SHIP. The overexpression of TAPP2 increases NFAT-dependent transcriptional activation after G cell Ag receptor ligation and increases the sustained phase of the calcium response. TAPP2 may play a role in the activation of B and T cells.