FBPase Anticuerpo(F-9): sc-166097

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Fructose-1,6-bisphosphatase (FBPase) mediates the key reaction of carbohydrate metabolism. It catalyzes the splitting of fructose-1,6-bisphosphate into fructose 6-phosphate and inorganic phosphate. FBPase is encoded by two genes, FBP1 and FBP2, which express the liver and muscle isoforms, respectively. FBPase appears to be present in all living organisms and is regulated by AMP inhibition in most species. Inhibition of FBPase by AMP affects the turnover of bound substrate and not its affinity for substrate. The liver FBPase isoform is composed of four identical subunits. Mutations in the FBP1 gene are inherited as an autosomal recessive disorder that leads to a deficiency of FBPase, which is associated with hypoglycemia and metabolic acidosis. Muscle FBPase is located on both sides of the z-line.