CA VIII Background Information Carbonic anhydrases (CAs) are members of a large family of zinc metalloenzymes responsible for catalyzing the reversible hydration of carbon dioxide. CAs show extensive diversity in their distribution and subcellular localization. They are involved in a variety of biological processes, including calcification, bone resorption, respiration, acid-base balance and the formation of aqueous humor, saliva, gastric juice and cerebrospinal fluid. CA VIII, also referred to as carbonic anhydrase-related protein VIII (CA-RP VIII), is a member of the carbonic anhydrase family that lacks the Zn-binding motif essential for carbonic anhydrase activity. For this reason, CA VIII does not exhibit catalytic activity but instead may be important in synaptic vesicle formation and transport. In addition, CA VIII may be involved in the invasiveness of non-small cell lung carcinomas and may also play a role in the growth of colon cancer cells.
CA VIII (B-5)
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CA VIII (B-5): sc-166069. Western blot analysis of CA VIII expression in mouse cerebellum tissue extract.
