GLIPR1 Anticuerpo(P-14): sc-162876

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GLIPR1 (GLI pathogenesis-related 1), also known as GLIPR, RTVP1 or CRISP7, is a 266 amino acid single-pass membrane protein belonging to the cysteine-rich secretory protein (CRISP) family. GLIPR1 also shares similarity with the pathogenesis-related protein (PR) superfamily, and may function as a p53 target gene with tumor suppressor functions. While ubiquitously expressed, GLIPR1 is found at highest levels in heart, lung, kidney, placenta, liver, skeletal muscle and cell lines derived from tumors of the nervous system. GLIPR1 expression is induced by p53 overexpression, exposure to gamma irradiation and doxorubicinis. The gene encoding GLIPR1 maps to human chromosome 12q21.2., and while alternatively spliced isoforms of GLIPR1 are known to exist, not all variants have been characterized.