SLC25A3 Anticuerpo(S-13): sc-161226

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Inner membrane mitochondrial proteins are responsible for the transport of metabolites across the mitochondrial membrane. SLC25A3 (solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3), also known as PHC or PTP (phosphate transport protein), is a 362 amino acid multi-pass inner mitochondrial membrane protein that belongs to the mitochondrial carrier family. SLC25A3 transports phosphate groups (and cotransports H+) to the mitochondrial matrix from cytosol, and exists as two alternatively spliced isoforms designated SLC25A3 isoform A and B. Highly expressed in pancreas, skeletal muscle and heart, SLC25A3 contains three solcar repeats and is encoded by a gene that maps to human chromosome 12q23.1. Defects in the gene encoding SLC25A3 are linked to mitochondrial phosphate carrier deficiency (MPCD), a disorder of oxidative phosphorylation that leads to death within the first year of life.