epitope mapping within an internal region of EDIL3 of human origin
recommended for detection of EDIL3 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including canine, bovine, porcine and avian
EDIL3 Background Information EDIL3 (EGF-like repeats and discoidin I-like domains 3), also known as developmentally-regulated endothelial cell locus 1 protein or integrin-binding protein DEL1, is a 480 amino acid secreted glycoprotein that may act as an angiogenic factor during solid tumor formation. Expressed in embryonic endothelial cells, EDIL3 acts a ligand of Integrin åV/∫3 to promote endothelial cell adhesion via an autocrine angiogenic signaling pathway. EDIL3 is also known to participate in vascular morphogenesis during embryonic development and is important for vessel wall remodeling. Containing three EGF-like domains and two F5/8 type C domains, EDIL3 exists as two alternatively spliced isoforms that are encoded by a gene mapping to human chromosome 5q14.3.
