BMP-2/4 Antibody (H-1): sc-137087
- BMP-2/4 Antibody (H-1) is a mouse monoclonal IgG2a κ BMP-2/4 antibody, cited in 46 publications, provided at 200 µg/ml
- raised against amino acids 300-350 of BMP-2/4 of human origin
- BMP-2/4 Antibody (H-1) is recommended for detection of precursor and mature BMP-2 and BMP-4 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine, bovine and porcine
- Anti-BMP-2/4 Antibody (H-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for BMP-2/4 Antibody (H-1) for WB applications. These reagents are now offered in bundles with BMP-2/4 Antibody (H-1) (see ordering information below).
BMP-2/4 Antibody (H-1) is a mouse monoclonal IgG2a kappa light chain antibody that detects BMP-2/4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BMP-2/4 Antibody (H-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. BMP-2/4 plays a crucial role in bone and cartilage development, acting as a signaling molecule that regulates cellular proliferation and differentiation. BMP-2/4 is primarily located in the extracellular matrix and is secreted by various cell types, which is essential for mediating the bone morphogenetic protein (BMP) signaling pathway. This pathway is vital for proper formation of bone and cartilage, and dysregulation can lead to various skeletal disorders. BMP-2/4 interacts with specific receptors, including type I and type II receptors, which possess intrinsic serine/threonine kinase activity, initiating a cascade of intracellular signaling events. Understanding BMP-2/4 localization and function is important for elucidating its role in developmental biology and potential therapeutic applications in regenerative medicine and tissue engineering.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
BMP-2/4 Antibody (H-1) References:
- Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis. | Ozkaynak, E., et al. 1992. J Biol Chem. 267: 25220-7. PMID: 1460021
- The transforming growth factor-beta family. | Massagué, J. 1990. Annu Rev Cell Biol. 6: 597-641. PMID: 2177343
- Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone. | Celeste, AJ., et al. 1990. Proc Natl Acad Sci U S A. 87: 9843-7. PMID: 2263636
- Association Between BMP-2 and Carcinogenicity. | Skovrlj, B., et al. 2015. Spine (Phila Pa 1976). 40: 1862-71. PMID: 26274524
- BMP-2-induced bone formation and neural inflammation. | Nguyen, V., et al. 2017. J Orthop. 14: 252-256. PMID: 28367006
- Endogenous BMP-4/ROS/COX-2 Mediated IPC and Resveratrol Alleviated Brain Damage. | Yan, Y., et al. 2019. Curr Pharm Des. 25: 1030-1039. PMID: 31113339
- Novel regulators of bone formation: molecular clones and activities. | Wozney, JM., et al. 1988. Science. 242: 1528-34. PMID: 3201241
- The Roles of GDF-9, BMP-15, BMP-4 and EMMPRIN in Folliculogenesis and In Vitro Fertilization. | Fountas, S., et al. 2024. J Clin Med. 13: PMID: 38999341
- Recombinant Vgr-1/BMP-6-expressing tumors induce fibrosis and endochondral bone formation in vivo. | Gitelman, SE., et al. 1994. J Cell Biol. 126: 1595-609. PMID: 8089189
- A human Mad protein acting as a BMP-regulated transcriptional activator. | Liu, F., et al. 1996. Nature. 381: 620-3. PMID: 8637600
- Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. | Zhang, Y., et al. 1996. Nature. 383: 168-72. PMID: 8774881
- Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. | McPherron, AC., et al. 1997. Nature. 387: 83-90. PMID: 9139826
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BMP-2/4 Antibody (H-1) | sc-137087 | 200 µg/ml | $322.00 | |||
BMP-2/4 Antibody (H-1): m-IgG Fc BP-HRP Bundle | sc-528858 | 200 µg Ab; 10 µg BP | $361.00 | |||
BMP-2/4 Antibody (H-1): m-IgGκ BP-HRP Bundle | sc-521423 | 200 µg Ab, 40 µg BP | $361.00 | |||
BMP-2/4 Antibody (H-1): m-IgG2a BP-HRP Bundle | sc-547193 | 200 µg Ab; 10 µg BP | $361.00 | |||
BMP-2/4 Antibody (H-1) AC | sc-137087 AC | 500 µg/ml, 25% agarose | $424.00 | |||
BMP-2/4 Antibody (H-1) HRP | sc-137087 HRP | 200 µg/ml | $322.00 | |||
BMP-2/4 Antibody (H-1) FITC | sc-137087 FITC | 200 µg/ml | $336.00 | |||
BMP-2/4 Antibody (H-1) PE | sc-137087 PE | 200 µg/ml | $349.00 | |||
BMP-2/4 Antibody (H-1) Alexa Fluor® 488 | sc-137087 AF488 | 200 µg/ml | $364.00 | |||
BMP-2/4 Antibody (H-1) Alexa Fluor® 546 | sc-137087 AF546 | 200 µg/ml | $364.00 | |||
BMP-2/4 Antibody (H-1) Alexa Fluor® 594 | sc-137087 AF594 | 200 µg/ml | $364.00 | |||
BMP-2/4 Antibody (H-1) Alexa Fluor® 647 | sc-137087 AF647 | 200 µg/ml | $364.00 | |||
BMP-2/4 Antibody (H-1) Alexa Fluor® 680 | sc-137087 AF680 | 200 µg/ml | $364.00 | |||
BMP-2/4 Antibody (H-1) Alexa Fluor® 790 | sc-137087 AF790 | 200 µg/ml | $364.00 |