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- rabbit polyclonal IgG, 100µg/ml
- epitope mapping within an internal region of Nucling of human origin
- recommended for detection of Nucling of mouse, rat and human origin by WB, IP, IF and ELISA
- blocking peptide, sc-135510 P
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Información sobre pedidos
Productos Recomendados para Ayudar:
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| Especie |
Nombre del Gen |
Identificacion del Gen |
Ubicacion del cromosoma |
Numero de Accesion de Isoforma (ARNm) |
Numero de Accesion de la Proteina |
Número de pedido: |
| Humano |
UACA |
55075 |
15q23 |
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Q9BZF9
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n/a |
| Ratón |
Uaca |
72565 |
9 B |
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Q8CGB3
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No Aplicable |
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Nucling Background Information
Nucling, also known as UACA (uveal autoantigen with coiled-coil domains and ankyrin repeats) and KIAA1561, is a 1,416 amino acid nuclear and cytoplasmic protein. Up-regulated after TSH-stimulation, Nucling is a component of the apoptosome complex, whose other components include Apaf-1 and caspase-9. Nucling interacts directly with Apaf-1 and regulates it’s redistribution to the nucleus following proapoptotic stress. Nucling also plays a role in the promotion of apoptosis by the galectin-3 down-regulation, apoptosome up-regulation and NF˚B inactivation pathways. Nucling also interacts with ARF6, which may modulate cell shape and motility following injury. Nucling contains six ANK repeats and is expressed highly in kidney, heart, pancreas and skeletal muscle. Nucling is a potential target autoantigen in Behcet disease (BD), Vogt-Koyanagi-Harada (VKH) and sarcoidosis, which cause different types of panuevitis. |
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Nucling (E-12)
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Nucling (E-12): sc-135510. Western blot analysis of Nucling expression in WI 38 whole cell lysate.
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