PIPK II/III Anticuerpo(N-19): sc-1330

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Phosphatidylinositol phosphate kinases (PIPKs) synthesize phosphatidylinositol-4,5-bisphosphate, which regulates various processes including cell proliferation, survival, membrane trafficking and cytoskeletal organization. The PIPK family is divded into three different classes, designated type I, type II and type III, each of which contain an activation loop, which determines their enzymatic specificity and subcellular targeting. The type I PIPKs (PIPK I) consist of PIPK I å, ∫ and ©, while the type II PIPKs (PIPK II) consist of PIPK II å and ∫, both of which exhibit high levels of expression in the brain. Type III PIPK (designated PIP5K III) localizes to the endosome membrane where it participates in endosome-related membrane trafficking and, like other PIPK proteins, generates phosphatidylinositol-4,5-bisphosphate via ATP-dependent phosphorylation. Due to their ability to regulate phosphatidylinositol-4,5-bisphosphate production, the PIPK proteins are essential messengers for signal transduction pathways throughout the body.